A new study finds that when p53, one of the most important cancer-protecting genes, stops working, cells produce too much RNA ...

Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and the middle. Is everything packed? What time should we leave? Will there be ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with ...

The researchers have identified a previously unknown mechanism, potentially shedding additional light on how tumors develop.

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

Researchers mapped RNA fragments embedded in human DNA, revealing a new genomic layer called the "ribome" that may shape gene activity.

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...