Novel structural insights into Phytophthora effectors challenge long-held assumptions in plant pathology

How do evolutionarily conserved pathogen effectors maintain structural stability while engaging diverse host targets? In a new study published in Molecular Plant Microbe Interactions, researchers at ...
Kaleido Scope

A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans

The study, "A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans,” was published in Immunity. “Our study ...

Strategic Innovation in Antibody Engineering: Creative Biolabs Addresses Key Challenges in ADCC and Fc Functionality

Creative Biolabs, a global leader in antibody engineering, today announced its optimization of ADCC and Fc-mediated ...
Hosted on MSN

Organ-specific inflammation masquerades as relapse in CAR T-cell remission

Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg have identified a previously undocumented, organ-specific toxicity linked to CD19-targeted CAR T-cell therapy in autoimmune disease.
Medscape

FDA Adds Boxed Warning for Immune Effector Cell-Associated Enterocolitis to CAR-T Drug

The FDA approved updated labeling for Carvykti (ciltacabtagene autoleucel, Janssen Biotech) to include a new boxed warning for immune effector cell-associated enterocolitis (IEC-EC). Carvykti is a ...
Medscape

New Syndrome With CAR T-Cell Therapy in Autoimmune Diseases

A substantial proportion of patients with autoimmune diseases experienced a new side effect called local immune effector cell–associated toxicity syndromes (LICATS) after receiving chimeric antigen ...