Chennai: One in four Indian breast cancer patients carries inherited genetic variants that raise cancer risk beyond the commonly tested BRCA1 and BRCA.

The human genome is a rich, complex record of migration, encounters, and inheritance written over thousands of millennia.

A study published today in the journal Science reveals how jumping fragments of human DNA, a type of genetic parasite, ...

DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair and chromosomal replication. Mutations in the POLE gene have ...

The final, formatted version of the article will be published soon. Introduction: Paclitaxel is a frontline chemotherapeutic agent that stabilizes microtubules, but its broader impact on germline ...

DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that aid DNA in carrying out essential processes such as replication, repair, and ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal metabolic processes or external stressors such as radiation or chemical ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic tangles overwhelm normal repair pathways, cells flip on a fast but error-prone ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...

A new fluorescent sensor is giving scientists an unprecedented view of how cells respond to DNA damage, capturing the repair process as it unfolds in real time. The tool, developed at Utrecht ...

Using comparative molecular biology with human cGAS – which actually inhibits DNA repair – the scientists found that the naked mole-rat's enzyme has four key changes that facilitate the important work ...

Mismatch repair deficiency (dMMR), microsatellite instability (MSI-H), and high tumor mutational burden (TMB-H) have emerged as clinically important biomarkers in prostate cancer with direct ...